A US sub picks up Navy SEALs and receives an order for a nuke launch. Due to the circumstances of the order, the Captain refuses to fire. After escaping an attack from another US sub, the crew and SEALs take refuge on a small island.

The show follows an organization that employs mind-wiped humans known as Dolls who are implanted with false memories and skills for various missions and tasks. When they are not 'at work' they are living in a real life Dollhouse which gives the show the name. One of those mind-wiped humans, a young woman named Echo, is slowly starting to become aware of herself and what's going on - all the while somebody on the outside is trying to bring the Dollhouse down while getting closer to Echo - possibly not aware that she is one of the Dolls he is after. Written by blank_dolls@livejournal.com

Mark leads a team of office workers whose memories have been surgically divided between their work and personal lives. When a mysterious colleague appears outside of work, it begins a journey to discover the truth about their jobs.